个人简介

从事皮肤性病临床、科研、教学、防治等工作30余年，擅长包括包括银屑病等红斑鳞屑性皮肤病、皮肤美容与面部年轻化、免疫性大疱病、结缔组织病和皮肤肿瘤等危重疑难皮肤病的诊疗。目前主要的研究方向是银屑病的基础和临床研究，培养博士生5名，硕士生12名。近5年来以第一作者或通讯作者发表SCI论文25篇，中文核心论文12篇。曾荣获广东省科技进步三等奖和广州市科技进步三等奖，马海德基金奖和“广东好医生”称号。现任广东省预防医学会皮肤性病防治专业委员会主任委员、广东省中西医结合学会美容专业委员会副主任委员、广东省中西医结合学会皮肤性病专业委员会副主任委员、广东省医院协会皮肤性病科管理专业委员会副主任委员、广东省麻风防治协会副理事长、中华医学会皮肤性病学分会治疗组委员、中国中西医结合学会皮肤科分会性病学组副组长、广东省医学会皮肤性病学分会常委及银屑病学组组长、广东省医师协会皮肤科医师分会常委、《皮肤性病诊疗学杂志》常务副主编等学术兼职，在皮肤性病专业领域具有较大的学术影响力。

研究领域

主要研究方向为银屑病及自身免疫性疱病的基础和临床研究。近十年承担的科研项目有：

1.广东省中医药局（重大疾病课题），20193011，靛玉红调控miRNA-17-3p-CTR9参与Th17细胞分化在儿童银屑病中的作用研究，2019.1.1-2021.1.1，20万，在研，主持

2.广东省科技厅，面上项目，191405000058，LNC00504作为ceRNA调控角质形成细胞增殖和分化影响银屑病发病的机制研究，2019.10.1-2022.0930，20万，在研，主持

3.广东省中医药局科研项目，20181181，养血解毒汤对小鼠银屑病样皮损IL-36β/IL-36R通路的影响，2018.01.05-2020.01.04，1万，已结题，主持

4. 广东省中医药局面上项目,20152026，凉血活血汤联合青黄膏对银屑病血热证Th17细胞的影响，2015.07-2017.06，16万，已结题，主持

5. 广东省科技厅面上项目，2014A020212233，Cx基因及其蛋白mRNA在一家系KID(角膜炎-鱼鳞病-耳聋综合征)皮肤组织中表达的研究，2015.06-2017.12，30万元，已结题，主持

个人成果

近年来第一作者或通讯作者发表的代表性文章

1.Zhang J, Huang X, Zhang Z, Zhao P, Chen W, Liang Y, Liu H, Zhong Z, Chen Y. Clinical observation of different doses of rituximab for the treatment of severe pemphigus: A single-center prospective cohort study. J Am Acad Dermatol. 2022 Jun 30:S0190-9622(22)02233-2. doi: 10.1016/j.jaad.2022.06.1187. Epub ahead of print. PMID: 35779637.

2.Liu S, Yuan X, Su H, Liu F, Zhuang Z, Chen Y. ZNF384: A Potential Therapeutic Target for Psoriasis and Alzheimer's Disease Through Inflammation and Metabolism. Front Immunol. 2022 May 20;13:892368. doi: 10.3389/fimmu.2022.892368. PMID: 35669784; PMCID: PMC9163351.

3.Ren JN, Su H, Xue RZ, Chen YF. Early diagnosis of Schöpf-Schulz-Passarge syndrome by whole-exome sequencing: the first Chinese case. J Eur Acad Dermatol Venereol. 2022 Sep;36(9):e722-e724. doi: 10.1111/jdv.18228. Epub 2022 May 28. PMID: 35592912

4.Huang X, Liang X, Zhang J, Su H, Chen Y. Pemphigus during the COVID-19 Epidemic: Infection Risk, Vaccine Responses and Management Strategies. J Clin Med. 2022 Jul 8;11(14):3968. doi: 10.3390/jcm11143968. PMID: 35887732; PMCID: PMC9317200.

5.Li Q, Zhang J, Liu S, Zhang F, Zhuang J, Chen Y. MicroRNA-17-3p is upregulated in psoriasis and regulates keratinocyte hyperproliferation and pro-inflammatory cytokine secretion by targeting CTR9. Eur J Histochem. 2022 Jan 12;66(1):3275. doi: 10.4081/ejh.2022.3275. PMID: 35016493; PMCID: PMC8764465.

6.Huang Y, Zhang Z, Zhu L, Chen Y. Treatment of Progressive Nodular Histiocytosis With Baricitinib. JAMA Dermatol. 2022 Mar 1;158(3):325-327. doi: 10.1001/jamadermatol.2021.5579. PMID: 35044417.

7.Chen Y, Li J, Zhu Y. Multicentric reticulohistiocytosis successfully treated with baricitinib. Eur J Dermatol. 2022 Jul 1;32(4):539-540. English. doi: 10.1684/ejd.2022.4307. PMID: 36301761.

8.Zhuang JY, Li JS, Zhong YQ, Zhang FF, Li XZ, Su H, Zhang ZQ, Wang XH, Chen YF. Evaluation of short-term (16-week) effectiveness and safety of guselkumab in patients with psoriasis: A prospective real-life study on the Chinese population. Dermatol Ther. 2021 Sep;34(5):e15054. doi: 10.1111/dth.15054. Epub 2021 Jul 11. PMID: 34228392.

9.Zhang ZQ, Zhang J, Chen YF. Harlequin syndrome. J Eur Acad Dermatol Venereol. 2021 Sep;35(9):e604-e605. doi: 10.1111/jdv.17337. Epub 2021 May 24. PMID: 33974302.

10.Lin J, Li X, Zhang F, Zhu L, Chen Y. Transcriptome wide analysis of long non-coding RNA-associated ceRNA regulatory circuits in psoriasis. J Cell Mol Med. 2021 Jul;25(14):6925-6935. doi: 10.1111/jcmm.16703. Epub 2021 Jun 2. PMID: 34080300; PMCID: PMC8278092.

11. Liu S, Geng R, Lin E, Zhao P, Chen Y. ERBB1/2/3 Expression, Prognosis, and Immune Infiltration in Cutaneous Melanoma. Front Genet. 2021 Mar 1;12:602160. doi: 10.3389/fgene.2021.602160. PMID: 33732282; PMCID: PMC7957073.

12.Fan F, Huang Z, Chen Y. Integrated analysis of immune-related long noncoding RNAs as diagnostic biomarkers in psoriasis. PeerJ. 2021 Mar 8;9:e11018. doi: 10.7717/peerj.11018. PMID: 33732554; PMCID: PMC7950217.

13.Zhuang JY, Li JS, Zhong YQ, Zhang FF, Li XZ, Su H, Zhang ZQ, Wang XH, Chen YF. Evaluation of short-term (16-week) effectiveness and safety of guselkumab in patients with psoriasis: A prospective real-life study on the Chinese population. Dermatol Ther. 2021 Sep;34(5):e15054. doi: 10.1111/dth.15054. Epub 2021 Jul 11. PMID: 34228392.

14.Li H, Yang C, Zhang J, Zhong W, Zhu L, Chen Y. Identification of potential key mRNAs and LncRNAs for psoriasis by bioinformatic analysis using weighted gene co-expression network analysis. Mol Genet Genomics. 2020 May;295(3):741-749. doi: 10.1007/s00438-020-01654-0. Epub 2020 Mar 3. PMID: 32125527.

15.Liu SG, Luo GP, Qu YB, Chen YF. Indirubin inhibits Wnt/β-catenin signal pathway via promoter demethylation of WIF-1. BMC Complement Med Ther. 2020 Aug 14;20(1):250. doi: 10.1186/s12906-020-03045-9. PMID: 32795328; PMCID: PMC7427955.

16.Zhang J, Xue R, Lin E, Pan H, Chen Y. Linear orofacial lichen sclerosus. Indian J Dermatol Venereol Leprol. 2018;84(2):197-199. doi: 10.4103/ijdvl.IJDVL_856_16. PMID: 29405132.

17.Liu H, Zhang J, Chen Y, Xue R, Zeng W, Xi L, Chen Y. Phaeohyphomycosis due to Exophiala spinifera greatly improved by ALA-PDT: A case report. Photodiagnosis Photodyn Ther. 2019 Dec;28:297-299. doi: 10.1016/j.pdpdt.2019.10.002. Epub 2019 Oct 10. PMID: 31606515.

18.Wang X, Wu X, Zheng B, Chen Y, Zheng D. Exome sequencing in a Chinese family reveals TTC9 mutation associated with keratitis-ichthyosis-deafness (KID) syndrome. Eur J Dermatol. 2018 Aug 1;28(4):534-535. doi: 10.1684/ejd.2018.3330. PMID: 30325323.

19.Li C, Zhang J, Wang W, Chen Y. Hydroxychloroquine combined with superficial X-ray-A new therapeutic method in the treatment of morphea profunda. Dermatol Ther. 2019 May;32(3):e12896. doi: 10.1111/dth.12896. Epub 2019 Apr 22. PMID: 30964567.

20.Zhong Z, Li J, Xue R, Liang Y, Chen Y. Refractory classic juvenile pityriasis rubra pilaris successfully treated with a combination of etanercept and methotrexate. Dermatol Ther. 2020 May;33(3):e13431. doi: 10.1111/dth.13431. Epub 2020 Apr 28. PMID: 32314486.

21.Zhu L, Yang C, Zhong W, Huang YQ, Zhang Q, Xu WC, Chen YF. KIT-related piebaldism in a Chinese girl. Am J Med Genet A. 2020 Jun;182(6):1321-1328. doi: 10.1002/ajmg.a.61576. Epub 2020 Mar 27. PMID: 32220041.

22.Zhong W, Yang C, Zhu L, Huang YQ, Chen YF. Analysis of the relationship between the mutation site of the SLC39A4 gene and acrodermatitis enteropathica by reporting a rare Chinese twin: a case report and review of the literature. BMC Pediatr. 2020 Jan 27;20(1):34. doi: 10.1186/s12887-020-1942-4. PMID: 31987033; PMCID: PMC6983971.

23.Li Q, Wang W, Zhuang J, Zhang J, Liu J, Chen Y. Improvements in two subtypes of porokeratosis by superficial X-ray radiotherapy. Dermatol Ther. 2020 Nov;33(6):e13876. doi: 10.1111/dth.13876. Epub 2020 Jul 8. PMID: 32558081.

24.Zhuang JY, Zhang FF, Li QW, Chen YF. Intra-abdominal inflammatory pseudotumor-like follicular dendritic cell sarcoma associated with paraneoplastic pemphigus: A case report and review of the literature. World J Clin Cases. 2020 Jul 26;8(14):3097-3107. doi: 10.12998/wjcc.v8.i14.3097. PMID: 32775392; PMCID: PMC7385594.

25.Li H, Zhang J, Chen Y. Methotrexate-induced toxic epidermal necrolysis in a child undergoing a combination therapy for systemic lupus erythematosus. Ital J Dermatol Venerol. 2021 Apr;156(2):263-264. doi: 10.23736/S2784-8671.20.06621-3. Epub 2020 Oct 9. PMID: 33034436.